

Profiles can have separate settings which is nice. I heavily use tab containers, but the site used for online grad school requires 3rd party cookies for any of the embedded content to work. So I have a separate school profile that has 3rd party cookies enabled.
My non technical spouse prefers profile to separate work and personal. She uses different themes for each profile so it is very obvious which is which.
Also one of the extensions she likes interferes with a work site she is required to use. She has that extension installed in the personal profile but not work profile.